{"id":113,"date":"2020-01-03T14:39:17","date_gmt":"2020-01-03T19:39:17","guid":{"rendered":"https:\/\/hoe2kwalvs.wpdns.site\/blog\/?p=113"},"modified":"2021-08-19T14:38:17","modified_gmt":"2021-08-19T19:38:17","slug":"how-an-opiate-blocking-medication-can-help-manage-chronic-pain","status":"publish","type":"post","link":"https:\/\/centralcompounding.com\/blog\/index.php\/2020\/01\/03\/how-an-opiate-blocking-medication-can-help-manage-chronic-pain\/","title":{"rendered":"Naltrexone (LDN): How an Opiate Blocking Medication Can Help Manage Chronic Pain"},"content":{"rendered":"<div class=\"vc_col-sm-6 wpb_column column_container col no-padding color-dark\" data-animation=\"\" data-delay=\"\">\n<div class=\"wpb_wrapper\">\n<div class=\"wpb_text_column wpb_content_element \">\n<div class=\"wpb_wrapper\">\n<div class=\"wpb_text_column wpb_content_element \">\n<div class=\"vc_col-sm-6 wpb_column column_container col no-padding color-dark\" data-animation=\"\" data-delay=\"\">\n<div class=\"wpb_wrapper\">\n<div class=\"wpb_text_column wpb_content_element \">\n<div class=\"wpb_wrapper\">\n<p>Naltrexone belongs to a class of drugs known as opioid\u00a0antagonists. Naltrexone blocks opiate drugs from binding to the opioid receptors, which can result in increased endorphin and enkephalin release. Therefore, this results in reduced: 1. signaling and release of inflammatory substances, 2. nerve cell inflammation and 3. autoimmune mediators.<\/p>\n<h3><strong>LDN and Chronic Pain<\/strong><\/h3>\n<p>Naltrexone received FDA approval for treating opioid addiction since 1984. While typical dose for treating opioid addiction with naltrexone is between 50 mg to 150 mg, the use of low dose naltrexone (LDN) with doses ranging from 1 mg to 6 mg per day has been growing in popularity. The most common use of LDN has been treating autoimmune disorders; consequently, there have been clinical trials investigating the effectiveness of LDN for clinical conditions such as multiple sclerosis, systemic sclerosis, and Crohn\u2019s disease.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"vc_col-sm-12 wpb_column column_container col no-padding color-dark\" data-animation=\"\" data-delay=\"\">\n<div class=\"wpb_wrapper\">\n<div class=\"spacer\">More recently, exploring the role low dose naltrexone and ultra-low dose naltrexone (microgram dosing of naltrexone) for chronic pain have been described in the literature.<\/div>\n<div class=\"wpb_text_column wpb_content_element \">\n<div class=\"wpb_wrapper\">\n<p>It has been proposed that\u00a0<strong>LDN halts inflammatory cascades<\/strong>\u00a0via glial cell inactivation. In addition, the role of microgram dosing of naltrexone has shown promise as a means to increase analgesia and decrease tolerance to opioid medications. This review evaluates the existing evidence for using LDN for treating pain and its microgram dosing in the potentiation of opioid medication while reducing side effects.<\/p>\n<p>Whether pain is from fibromyalgia, rheumatoid arthritis, osteoarthritis or CRPS LDN should be weighed as a therapeutic option.<\/p>\n<p>Ask our pharmacists!<\/p>\n<p>Key words: LDN, naltrexone, Durham<\/p>\n<p><em>References: <\/em><\/p>\n<p><em><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24526250-the-use-of-low-dose-naltrexone-ldn-as-a-novel-anti-inflammatory-treatment-for-chronic-pain\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/24526250-the-use-of-low-dose-naltrexone-ldn-as-a-novel-anti-inflammatory-treatment-for-chronic-pain\/<\/a><\/em><\/p>\n<p><a href=\"https:\/\/www.alliedacademies.org\/articles\/treating-chronic-pain-with-low-dose-naltrexone-and-ultralow-dose-naltrexonea-review-paper-11183.html\">https:\/\/www.alliedacademies.org\/articles\/treating-chronic-pain-with-low-dose-naltrexone-and-ultralow-dose-naltrexonea-review-paper-11183.html<\/a><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Naltrexone belongs to a class of drugs known as opioid\u00a0antagonists. Naltrexone blocks opiate  [&#8230;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"link","meta":{"footnotes":""},"categories":[3,6],"tags":[36,17,7,37,16],"class_list":["post-113","post","type-post","status-publish","format-link","hentry","category-general","category-naltrexone","tag-durham","tag-fibromyalgia","tag-ldn","tag-nc","tag-pain","post_format-post-format-link"],"_links":{"self":[{"href":"https:\/\/centralcompounding.com\/blog\/index.php\/wp-json\/wp\/v2\/posts\/113","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/centralcompounding.com\/blog\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/centralcompounding.com\/blog\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/centralcompounding.com\/blog\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/centralcompounding.com\/blog\/index.php\/wp-json\/wp\/v2\/comments?post=113"}],"version-history":[{"count":3,"href":"https:\/\/centralcompounding.com\/blog\/index.php\/wp-json\/wp\/v2\/posts\/113\/revisions"}],"predecessor-version":[{"id":168,"href":"https:\/\/centralcompounding.com\/blog\/index.php\/wp-json\/wp\/v2\/posts\/113\/revisions\/168"}],"wp:attachment":[{"href":"https:\/\/centralcompounding.com\/blog\/index.php\/wp-json\/wp\/v2\/media?parent=113"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/centralcompounding.com\/blog\/index.php\/wp-json\/wp\/v2\/categories?post=113"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/centralcompounding.com\/blog\/index.php\/wp-json\/wp\/v2\/tags?post=113"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}